HYPERCOAGULATION
Updated: 6 days ago
Please don't let this topic scare you. I only share it because it does come up, and there are some great tools doctors use to help with it.
A quick-view graphic with the key points is at the bottom of this post.
The supplements recommended by Rise Above Lyme are listed at the bottom of this post for easy shopping.
WHAT IT IS
- Hypercoagulation means the blood clots more easily than it should. You may hear it called "sticky blood" or "thick blood."
- Dr. Todd Maderis explains that inflammation from viruses, bacteria, mold and MCAS can switch on the body's clotting process. This can leave a thin layer of fibrin, a sticky clotting protein, along the inside of blood vessels.
- Dr. Marty Ross shares that this happens in many chronic infections. The fibrin deposits can slow blood flow through tiny blood vessels, so tissues get less oxygen.
WHY IT MATTERS IN LYME
- Dr. Maderis explains that when blood flow slows, less oxygen, fewer nutrients and fewer hormones reach the cells, and waste is cleared more slowly.
- Dr. Ross shares that slower blood flow can also make it harder for antibiotics and herbs to reach the tissues where Lyme and co-infections live.
- Dr. Ross also shares that Babesia and Bartonella can hide in fibrin "nests" along blood vessel walls, away from the immune system and treatment.
- Dr. Maderis notes that fibrin can add to biofilms, where infections can hide.
SYMPTOMS DR. MADERIS CONNECTS TO IT
- Aching, deep or stabbing pain
- Brain fog, irritability, anxiety and mood swings
- Trouble sleeping and restless legs
- Stiffness after waking up or sitting for a while
- Nausea or a low appetite in the morning
- Fatigue and feeling worse after exercise
- Cold hands and feet, or blotchy (mottled) skin
- Swelling in the legs or redness in the feet
- Feeling lightheaded when changing positions
He also shares a simple sign: press on a fingernail and let go. In a healthy state, the pink color comes back in 2 seconds or less. A slower return can be a sign of poor blood flow.
LABS
These are tests doctors may use to look for hypercoagulation. Ask your doctor which ones are right for you.
- Prothrombin Fragment 1 + 2
- Anti-thrombin Activity
- Lipoprotein (a)
- Alpha-2-Antiplasmin
- D-Dimer
- Fibrinogen Activity
- Plasminogen Activator Inhibitor (PAI-1)
- Factor II Activity
- Homocysteine
- Protein C Activity
- Protein S Activity
- Thrombin-Antithrombin Complex
Dr. Maderis shares that a coagulation panel with many of these tests can be ordered through LabCorp under code 505443.
WHAT THE RESEARCH SAYS
- A 2024 review by Johns Hopkins researchers noted that tiny fibrin clots and overactive platelets have been found in people with long COVID, and these may block small blood vessels. The authors said more studies are needed. They also noted that no human studies have yet looked at blood vessel lining problems in post-treatment Lyme.
- Mount Sinai and the PolyBio Research Foundation have a clinical trial of lumbrokinase in long COVID, ME/CFS and chronic Lyme (the study calls it "long Lyme"). It is looking at whether lumbrokinase is well tolerated, whether symptoms improve and whether it breaks up these tiny clots. The chronic Lyme part is supported by the Cohen Foundation's clinical trials network for Lyme and other tick-borne diseases. No results have been shared yet.
WHAT LYME DOCTORS USE
- Dr. Maderis calls fibrin-breaking enzymes, like lumbrokinase, the main tool for hypercoagulation. He suggests starting with a low dose.
- I use Boluoke now, and I have rotated here and there with the Allergy Research Group and Researched Nutritionals brands. I was also told to increase it after having Covid.
- Learn more about Boluoke, how doctors use it and how to take it:
PLEASE BE CAREFUL
Talk with your doctor about testing and before adding anything, especially if you take blood thinners, have a bleeding disorder or have surgery coming up.
HOW TO BUY AT 25% OFF
Name brand Boluoke:
Need 25% off Boluoke? Email us to arrange that discount with your practitioner at theriseabovelyme@gmail.com
Lumbrokinase on Fullscript:
Anyone can get 25% off when signed up under the Rise Above Lyme Fullscript discount:
Lumbrokinase by Researched Nutritionals:
Lumbrokinase by Allergy Research Group:
RELATED POSTS
Lumbrokinase / Boluoke (compare brands and save):
Biofilms:
Mast Cell / MCAS:
SOURCES
Dr. Todd Maderis, Hypercoagulation in Lyme Disease (updated 2025)
Dr. Marty Ross, Lumbrokinase in tick-borne diseases (updated 2026)
Adler, Chung, Rowe and Aucott, Dysautonomia following Lyme disease, Frontiers in Neurology (2024):
PolyBio Research Foundation and Mount Sinai, Lumbrokinase clinical trial for long COVID, ME/CFS and long Lyme (2024):
Disclaimer: Rise Above Lyme makes no claims about any possible benefit of using any product mentioned within this site. Always consult with your doctor before adding anything. The information shared is based on personal experience, years of accumulated researched resources from Lyme Literate doctors and polls conducted within Lyme groups from actual patient experience using these solution ideas.
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