BOLUOKE
Updated: Oct 18
Boluoke is the name brand of lumbrokinase, an enzyme that many Lyme literate doctors use. It is the brand most often recommended in our groups. I use Boluoke now, and I have rotated here and there with the Allergy Research Group and Researched Nutritionals brands. I put all the ways to get it at 25% off below.
A quick-view graphic with the key points is at the bottom of this post.
The supplements recommended by Rise Above Lyme are listed at the bottom of this post for easy shopping.
WHAT IT IS
- Lumbrokinase is a group of enzymes taken from earthworms.
- It breaks down fibrin, a sticky protein involved in blood clotting.
- Boluoke is a name brand of lumbrokinase, made by Canada RNA.
- Each Boluoke capsule holds 20 mg of lumbrokinase.
- The company reports Boluoke has gone through all phases of clinical trials in China, with the largest trial including 16 hospitals.
WHY LYME DOCTORS USE IT
- Biofilms: Dr. Marty Ross explains that fibrin helps hold together the slimy layer (biofilm) where Lyme germs can hide. Lumbrokinase may help break it apart. He shares that this hasn't been proven in Lyme studies yet, but in his practice many patients do much better when it's added.
- Hiding spots: Dr. Ross also shares that Babesia and Bartonella can hide in fibrin "nests" along blood vessel walls, away from the immune system and treatment.
- Sticky blood (hypercoagulation): Dr. Todd Maderis explains that inflammation from infections, mold and MCAS can make the blood thick and sludgy, so less oxygen and fewer nutrients reach the body. He calls fibrin-breaking enzymes like lumbrokinase the main tool for this.
- Helping treatment reach deeper: Dr. Ross shares that better blood flow may help medicines and supplements reach the tissues where infections live.
- Research underway: Mount Sinai has a clinical trial of lumbrokinase in long COVID, ME/CFS and chronic Lyme (the study calls it "long Lyme"). No results have been shared yet. You can read more in my Hypercoagulation post.
HOW TO TAKE IT
- Take it on an empty stomach. Dr. Maderis suggests at least 30 minutes before or two hours after a meal. Dr. Ross suggests no food, medicines or supplements from 1 hour before until 1 hour after.
- Start low. Dr. Maderis suggests starting with a low dose, and Dr. Ross notes that die-off (herx) reactions can happen.
- Keep the capsules whole. They are made to get past stomach acid, which can make the enzyme stop working.
- Space it at least 2 hours away from other enzymes.
- Your doctor can guide you on the right amount.
PLEASE BE CAREFUL
- Not for anyone with a bleeding disorder, stomach ulcers or bleeding in the gut.
- Stop it 1 week before surgery, and ask your doctor when to restart.
- Talk with your doctor first if you take blood thinners or anti-platelet medicines like Plavix.
- Ask your doctor first if you are pregnant or nursing.
- Not for anyone allergic to earthworms.
HOW TO BUY AT 25% OFF
Name brand Boluoke:
Need 25% off Boluoke? Email us to arrange that discount with your practitioner at theriseabovelyme@gmail.com
Lumbrokinase on Fullscript:
Anyone can get 25% off when signed up under the Rise Above Lyme Fullscript discount:
Lumbrokinase by Researched Nutritionals (its own formula, not Boluoke):
Lumbrokinase by Allergy Research Group:
Compare the brands and see my notes here:
ADDITIONAL RESOURCES
Hypercoagulation:
Biofilms:
Biofilm solutions:
Enzymes:
Serrapeptase:
High cholesterol (in relation to Lyme and co-infections):
Herx solutions:
Disclaimer: Rise Above Lyme makes no claims about any possible benefit of using any product mentioned within this site. Always consult with your doctor before adding anything. The information shared is based on personal experience, years of accumulated researched resources from Lyme Literate doctors and polls conducted within Lyme groups from actual patient experience using these solution ideas.
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